Exploring AAV subspecies using single molecule mass detection Eduard H.T.M. Ebberink1, Alisa Ruisinger2, Markus Neubel2, Marco Thomann2, Albert J.R. Heck1 1 Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, the Netherlands2 Roche Diagnostics, Penzberg, Germany Introduction: Adeno-associated viruses (AAV) […]
Probing viral capsid assembly by native MS Lars Thiede1,2, Ronja Pogan1,2, Jürgen Müller-Guhl1,3, Charlotte Uetrecht1,2,3 1 Centre for Structural Systems Biology (CSSB), Deutsches Elektronen-Synchroton DESY, Leibniz Institute of Virology (LIV), Hamburg, Germany.2 Faculty V: School of Sciences, University of Siegen, Siegen, Germany.3 Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany The assembly of viral
Probing the Structure and Dynamics of Proteins by Means of Cyclic Ion Mobility Spectrometry and Electron Capture Dissociation Kostas Thalassinos1 1. University College London Modern protein prediction methods using deep neural networks can now achieve extremely accurate results when predicting protein structures from the protein’s sequence. Despite this impressive achievement these approaches still struggle to
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Hyphenating Ion Mobility and Action Spectroscopy in a Synapt G2 to Probe the Structure and Kinetics of Aggregating Peptides Steven Daly1, Sjors Bakels2, Agathe Depraz2, Iuliia Stroganova2, Jan Commandeur1, Anouk M. Rijs2 1 MS Vision,Televisieweg 40, 1322AM Almere, The Netherlands2 Division of BioAnalytical Chemistry, AIMMS Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam,
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Establishing proteoform footprints of 20S proteasomes from biological and patient samples using top-down mass spectrometry Angelique Sanchez Dafun1; Dušan Živković1; Stephen Adonai Leon Icaza1; Sophie Möller2; Carine Froment1; Delphine Bonnet3,4; Adriana Almeida De Jesus5; Laurent Alric4; Muriel Quaranta-Nicaise3; Audrey Ferrand3; Céline Cougoule1; Etienne Meunier1; Odile Burlet-Schiltz1; Frédéric Ebstein2,†; Raphaela Goldbach-Mansky5; Elke Krüger2; Marie-Pierre Bousquet1; Julien
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Using native mass spectrometry to determine the strength of molecular glues Aneika Leney1 School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K. Approximately 300,000 protein-protein interactions (PPI) occur in human cells. The disruption of these PPIs into their individual protein constituents contributes to many human diseases including cancer and neurodegeneration. Thus, there is
